During the Prince Mahidol Award Conference (PMAC) 2021, SIGHT, with support from the Swedish Ministry for Foreign Affairs, coordinated subtheme four: “COVID-19 and the global megatrends”. This included the co-delivery of five webinars and a plenary session together with Ashley McKimm (BMJ), Rintaro Mori (UNFPA), John Balbus (NIEHS), the WHO and USAID, amongst other collaborators. This year in a virtual form, PMAC presented speakers from 35 different countries and a global audience from 87 countries, discussing topics of global health, the direct and indirect effects of the pandemic, as well as solutions for progress towards the 2030 Agenda. We invite you to listen to the discussions in these recorded webinar sessions. We also invite you to listen in on the other subthemes’ webinar sessions on the PMAC website.